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Pioneers in AAV delivery Over the past two decades, the Spark leadership team has developed unrivaled expertise in the design, manufacturing and delivery of gene therapies using adeno-associated virus (AAV) vectors. High, M.D, a gene therapy pioneer who has served as the director of the CCMT since its inception. Iowa City, Iowa, United States. We look forward to working with Pfizer with the goal of making gene therapy for hemophilia B a reality for patients.". All news about SPARK THERAPEUTICS INC. CombiGene's and Neurochase's preclinical study provides valuable information for the up.. GMP production of CG01 made available for preclinical studies planned to enable First i.. Spark Therapeutics was founded in 2013 and became a Member of the Roche Group in 2019. The company is also advancing toward the clinic with gene therapy programs to address neurodegenerative diseases and additional hematologic disorders and other forms of inherited blindness. Many of the CCMT's leaders will assume management roles within Spark or engage with the company as scientific advisors, including Katherine A. Spark will be responsible for conducting all Phase 1/2 studies while Pfizer will assume responsibility for pivotal studies, any regulatory approvals and potential global commercialization of the product. from 8 AM - 9 PM ET. . About. There is currently no pharmacologic treatment for this form of inherited retinal degeneration, which ultimately causes irreversible blindness. from 8 AM - 9 PM ET. This feature is in beta and may change with future updates. They acquired Genable Technologies Ltd. for $15.2M. PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today . AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Descriptive keyword for an Organization (e.g. The open-label, randomized, controlled study builds on an earlier clinical study in which 12 patients with RPE65-related blindness demonstrated notable improvement in visual function, moving in some cases from being profoundly blind to being able to recognize faces and ambulate independently. Detailed information on company financials and operating reports can be found here: . Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. Spark Therapeutics is developing curative, one-time gene therapy products with the potential to transform the lives of patients and re-imagine the treatment of . Spark has rights to a proprietary manufacturing platform that has a track record supporting clinical studies across diverse therapeutic areas and routes of administration. Spark Therapeutics, Inc. Feb 2020 - Dec 2020 11 months. Philadelphia, Pennsylvania, United States . Spark Therapeutics Launched with $50 Million in Financing to Advance Late- and Mid-Stage Gene Therapy Programs with Clinical Proof of Concept . Dr. Hanadie Yousef is a scientist with expertise in stem cell, neuro and aging biology, and the co-founder and CEO of Juvena Therapeutics, a computationally driven protein drug discovery . October was an important month for Spark Therapeutics . The company's expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Spark's team while at The Children's Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. Spark Therapeutics, Inc. Spark will assume control over two gene therapy clinical trials: a Phase 3 study for inherited blindness caused by mutations of the RPE65 gene and a Phase 1/2 study for hemophilia B. The Company focuses on treating orphan diseases. Find company research, competitor information, contact details & financial data for Spark Therapeutics, Inc. of Philadelphia, PA. Get the latest business insights from Dun & Bradstreet. Champion Double Platinum Spark Plug 7034. To learn more please visit the Spark website at www.sparktx.com/pipeline/hematologic-disorders. Developed and implemented strategic repositioning, restructuring, and full operational management . Associate Professor of Neurology. Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American, www.sparktx.com/pipeline/hematologic-disorders, http://www.prnewswire.com/news-releases/spark-therapeutics-announces-gene-therapy-collaboration-in-hemophilia-b-with-pfizer-inc-300005849.html. Spark's initial focus is on treating orphan diseases where no, or only palliative therapies, exist. Spark's hemophilia B program has the potential to build on our leading hemophilia portfolio and could offer patients with this bleeding disorder a potential new treatment option.". These include Viewport Meta, IPhone / Mobile Compatible, and SPF. It is a subsidiary of Hoffmann-La Roche. Oversee the development of medical strategies for Spark products that can be used to guide developme. Spark Therapeutics, Inc. is a developer of gene therapy treatments, which treat debilitating genetic diseases. To learn more visit www.sparktx.com. Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. R&D in Biotech, Environmental and various industries (no marketing product yet) Tags Biotechnology, Healthcare Venture Deals, Healthcare IPO Companies managed Acquired/Merged Spark Therapeutics Headquarters 3737 Market Street Suite 1300 Philadelphia, PA 19104 US (888) 772-7560 info@sparktx.com Web Site N/A Milestones Related Companies Seed, Series A, Private Equity), Whether an Organization is for profit or non-profit, General contact email for the organization, Auto-generated name of transaction (e.g. and menstrual hygiene products to women experiencing homelessness . "With their experience in the field of gene therapy, as well as in the research and development of potential novel treatments for hemophilia, we believe that Spark's team of scientists and clinicians will complement Pfizer's expertise in helping to bring a new therapy to patients," said Kevin Lee, senior vice president and chief scientific officer, Rare Disease Research Unit, Pfizer. Spark Therapeutics, Inc. insights Based on 10 survey responses What people like Ability to learn new things Time and location flexibility Fair pay for job Areas for improvement Energizing work tasks Sense of belonging Overall satisfaction The best job I'll ever have Quality Control Analyst (Former Employee) - Philadelphia, PA - February 20, 2022 Fully Integrated Gene Therapy Company with Deep Clinical Pipeline Spun out of The Children's Hospital of Philadelphia. WhatsApp acquired by Facebook). After extensive research and analysis, Zippia's data science team found the following key financial metrics. Types of diversity represented in an organization, specifically of those who are founding members, currently the CEO, or have check-writing abilities in an investment firm. Spark's most advanced clinical program is a Phase 3 study to address blindness caused by mutations in the RPE65 gene. Type Public Founded 2013 HQ Jul 2013 - Jul 20141 year 1 month. Spark Therapeutics, Inc. 3737 Market Street Philadelphia, PA 19104 Phone: 1-855-SPARKTX / +1 215-220-9300 2022 Spark Therapeutics, Inc. P-RPE65-US-450002-10 Pfizer is a leader in hemophilia, developing the first recombinant Factor IX product," said Dr. Katherine High, a hematologist and co-founder, president and chief scientific officer of Spark. Spark Therapeutics's new tradmarks suggest it is investing in R&D . At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of . Head of Corporate Security. It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. "We believe Pfizer is the ideal partner for our hemophilia B program. Spark Therapeutics is an equal opportunity employer. Name of the organization that made the acquisition, Stock ticker symbol (e.g. To learn more, visitwww.sparktx.com. Notably, Spark has exclusive rights to commercialize CHOP's proprietary manufacturing technology and will use clinical . The eye-popping $4.8 billion sticker price on Spark Therapeutics' acquisition deal with Roche announced on Monday is shaping up to be the largest exit ever within city limits for a venture-backed company, according to data from financial data provider PitchBook and the Philadelphia Alliance for Capital and Technologies (PACT). [1] It is a subsidiary of Hoffmann-La Roche . How much funding has this organization raised over time? This study builds on the Spark team's previous groundbreaking work in advancing the first two gene therapy clinical studies in hemophilia B, the second of which achieved the highest levels of factor IX expression of any gene therapy trial to date. Their latest funding was raised on May 27, 2014 from a Series B round. Spark Therapeutics, Inc. is a gene therapy company. Acting Vice-Chair for Education, Department of Neurology. Spark Therapeutics has acquired Genable Technologies Ltd. on Mar 7, 2016. AAV has been demonstrated in clinical studies to be a safe and effective vehicle for the delivery of genetic material into targeted cells and provides unique advantages over alternative delivery approaches. Spark Therapeutics' relocation gives more space to the laboratory functions with approximately 22,700-square-feet of lab space, 14,800-square-feet of office/meeting/amenity space, and an additional11,200-square-feet of building support and core on the second floor and 9,000-square-feet on the garden level. "Their vision and long-term dedication have enabled us to effectively address many of the key challenges facing the field and to emerge with one of the industry's most robust clinical-stage gene therapy pipelines; as well as exclusive rights to commercialize a proprietary manufacturing platform, supply from a world-class manufacturing facility and a founding team with a proven track record of executing safe and effective gene therapy trials for nearly two decades. Raised over time upside in the following years and full operational management spark or engage with the aim of an! 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